Members of train drivers’ unions RMT and ASLEF are walking out on Wednesday and Friday in a row over pay.
The strike will affect the line between Manchester Piccadilly and York, which calls at Huddersfield, Dewsbury and Leeds.
The line between Manchester stations and Manchester airport will also be affected.
Train operator First TransPennine is planning a limited timetable.
For full details, click the link to the right.