Batley Bulldogs will visit fellow Co-operative Championship side Hunslet Hawks in the Carnegie Challenge Cup fourth round while Dewsbury Rams face a difficult trip to tackle the London Broncos.
The draw was made on Monday evening at the DW Stadium in Wigan.
Ties are scheduled to be play on the weekend of April 14 and 15.
Challenge Cup fourth round draw:
London Broncos v Dewsbury Rams
Widnes Vikings v St Helens
Leeds Rhinos v Wakefield Trinity Wildcats
Whitehaven v Salford City Reds
Featherstone Rovers v Castleford Tigers
Hull FC v Huddersfield Giants
Wigan v North Wales Crusaders
Swinton Lions v Gateshead Thunder
Hull Kingston Rovers v Catalans Dragons
Bradford Bulls v Doncaster
South Wales Scorpions v Halifax
York City Knights v Sheffield Eagles
Keighley Cougars v Warrington Wolves
Leigh Centurions v Rochdale Hornets
Oldham v Barrow Raiders
Hunslet Hawks v Batley Bulldogs