The 39 men and three women appeared before Leeds Crown Court yesterday (Wednesday).
They have been charged with a variety of mainly sexual offences as part of an investigation into non-recent child sexual exploitation.
The allegations against the defendants involve offences committed against six female victims, who were children at the time the alleged offending began.
Those alleged offences occurred between 1995 and 2015, largely in the Dewsbury and Batley areas
Those charged with offences are from Dewsbury, Batley, Heckmondwike, Keighley, Bradford, Birmingham and Mirfield.